Amy Schumer has been transparent about her health journey over the years. The Trainwreck actress first opened up about her weight loss journey when she revealed she underwent liposuction in 2022. "It's not about needing to be slamming, because I've never been famous for being hot, but I'd reached a place where I was tired of looking at myself in the mirror," she explained to The Hollywood Reporter that year.
After her surgery, Schumer began taking Wegovy for weight loss and quickly lost 30 lbs. However, she decided to quit the medication after having a "horrible experience" with nausea and feeling like she was "shriveling away."
Three years after quitting the GLP-1 drug, Schumer tried Mounjaro, a different version of the type 2 diabetes drug, and had a "really good experience." Since then, Schumer has been sharing updates on Instagram and showing off her transformation.
In 2022, Schumer opened up about her decision to get liposuction after getting her uterus and appendix removed in September 2021 to help her endometriosis, and after welcoming her son Gene via C-section.
Sharing a photo of herself posing in a black one-piece swimsuit on the beach on Instagram, she wrote, "I feel good. Finally. It's been a journey thanks for helping me get my strength back @seckinmd(endo) @jordanternermd (lipo). Never thought i would do anything but talk to me after your uterus doesn't contract for 2.5 years and you turn 40."
Schumer also revealed in her Instagram Stories at the time that she was 170 lbs. post-procedures.
In March 2022, she explained it was important for her to be open about her surgery with her followers and other people going through something similar.
"I just wanted to say that, because if anybody sees me in pictures or anything and they're like, she looks thinner, and whatever: it's because I had a surgery," she said on Chelsea Handler's podcast Dear Chelsea in March 2022. "It's too hard, and I just want to be real about it."
After undergoing the procedures, Schumer continued her weight loss journey by taking Wegovy. Although the medication worked for Schumer, the side effects took such a toll on her that she had to quit.
"I was one of those people that felt so sick and couldn't play with my son," she first shared on Watch What Happens Live with Andy Cohen in June 2023. "I was so skinny and he's throwing a ball at me and [I couldn't]."
She added, "And you're like, 'OK, this isn't livable for me.' But I immediately invested [in it] because I knew everyone was going to try it."
The comedian spoke about her "horrible experience" with the medication again during a January 2025 appearance on Howard Stern's SiriusXM show.
"I have this gene, GDF15, which makes you extremely prone to nausea, which is why I was so sick during my pregnancy," Schumer explained. "So, I tried Ozempic almost three years ago and I was like bedridden. I was like vomiting -- and then you have no energy. But other people take it and they're all good. So, God bless them."
Schumer remembered that the weekly injections made her feel so nauseous that she felt like she was "shriveling away."
"I lost 30 pounds so quick. I looked great, but I couldn't lift my head off the pillow. So what's the point?" she asked.
During Schumer's rise to fame, she became accustomed to people talking about her physical appearance. However, some of her fans' comments about her "puffier" face led Schumer to see a doctor who diagnosed her with Cushing syndrome.
Cushing syndrome is a condition where the body has too much cortisol (the primary stress hormone), per the Mayo Clinic. In addition to developing a rounder face from weight gain, some of the other symptoms include weight gain in the arms and legs, high blood pressure and increased stretch marks.
"While I was doing press on camera for my Hulu show, I was also in MRI machines four hours at a time, having my veins shut down from the amount of blood drawn and thinking I may not be around to see my son grow up. So finding out I have the kind of Cushing that will just work itself out and I'm healthy was the greatest news imaginable," Schumer said in Jessica Yellin's "News Not Noise" newsletter in February 2024.
Schumer acknowledged that having people comment on her physical appearance is unique but in this case it was helpful for her in the long run.
"It has been a crazy couple [of] weeks for me and my family," she said. "Aside from fears about my health, I also had to be on camera having the internet chime in. But thank God for that. Because that's how I realized something was wrong."
She continued saying, "Everyone is struggling with something. Maybe we can all be a little kinder to each other and ourselves."
Around three years after she had a "horrible experience" with Ozempic, Schumer tried using a different brand, Mounjaro, with similar weight loss ingredients. In March 2025, Schumer posted an Instagram video of her talking about her second shot at the medication.
"I was like puking, I couldn’t handle it. I don’t know if they’ve changed the formula, whatever," she said of her first experience to her second. "So, yeah—that’s been great. Mounjaro’s been great."
The Kinda Pregnant star said that she had been "having a really good experience so I wanted to keep it real with you about that," she added.
In addition to being open and honest about her weight over the years, Schumer has also been transparent about her endometriosis and her perimenopause symptoms.
"I have endometriosis an auto immune disease that every woman should read about," she wrote on Instagram in February 2024. "There are some medical and hormonal things going on in my world right now but I'm okay."
A little over one year later, Schumer took to Instagram in the same Mounjaro video to share an update and revealed that she was prescribed two hormones, estrogen and progesterone, for her conditions.
"My symptoms of being in perimenopause have disappeared. My hair is fuller; my skin is better; I have more energy. I want to 'get down' more if you know what I mean," she said.
Throughout her health journey, Schumer has advocated for women's health while also expressing how important it is for people to be transparent about their weight loss.
"I wanted to take the opportunity to advocate for self love and acceptance of the skin you're in," she wrote on Instagram in February 2024. "Like every other women/person some days I feel confident and good as hell and others I want to put a bag over my head."
After Schumer revealed that she got liposuction, she said that she wanted to be honest about procedures she's undergone.
"I just wanted to say that, because if anybody sees me in pictures or anything and they're like, she looks thinner, and whatever: it's because I had a surgery," she said on Dear Chelsea in 2022. "It's too hard, and I just want to be real about it."
Schumer doubled down on her thoughts on transparency in 2023 after sharing that she had taken a weight loss medication for the first time.
"Everyone has been lying saying, 'Oh smaller portions.' Like shut the f--- up. You are on Ozempic or one of those things or you got work done. Just stop," she said on Watch What Happens Live. "Be real with the people. When I got lipo, I said I got lipo."
Meanwhile, after Schumer publicly shared her "personal" Cushing syndrome diagnosis in 2024, she said that she wanted to "advocate for women's health."
"The shaming and criticism of our ever-changing bodies is something I have dealt with and witnessed for a long time," she said in an Instagram video. "I want so much for women to love themselves and be relentless when fighting for their own health in a system that usually doesn't believe them."