Arizona investigators are racing against the clock as they desperately search for Savannah Guthrie's abducted mother, who police say could die without her medication.
The Daily Mail revealed how the 84-year-old had been abducted from her bed at her $1 million home in Tucson, Arizona, late Saturday or early Sunday.
Pima County Sheriff Chris Nanos emphasized that the devout mother of three could die without her medication during an interview on Tuesday.
'It is a race against time, and I hope that window hasn't closed,' Nanos.
Meanwhile, the Today Show host was absent from the anchor's desk for a second day on Tuesday as the search for her mother continues.
Instead, she made a heartbreaking plea for fans to keep her beloved mother in their prayers to help 'bring her home.'
Search for Nancy Guthrie is 'a race against time,' sheriff says
Pima County Sheriff Chris Nanos said it is imperative that Nancy Guthrie be found soon because she could die without her medication.
'It is a race against time, and I hope that window hasn't closed,' Nanos told the Today Show.
He also revealed that investigators collected DNA evidence at the crime scene early Tuesday morning.
'We took some samples that we hope will have enough profile of a DNA profile that gives us some identification of what we're looking at,' he said.
The 84-year-old had been abducted from her bed at her $1 million home in Tucson, Arizona, late Saturday or early Sunday.
Savannah Guthrie's sister last person to see missing mom
Today Show host Savannah Guthrie's sister, Annie, spent the evening having dinner with their mother Nancy just hours before the 84-year-old woman vanished.
She had enjoyed a dinner with Annie before playing mahjong - a popular four-player tile game that Nancy had posted about on January 24.
The daughter then returned to her $1million home in Tucson's affluent Catalina Foothills neighborhood at around 9.45pm.
Annie - who once called her mother 'our bright north star' - said she did not notice any 'red flags' about her mother's behavior during the dinner.
Savannah Guthrie's sister who was last person to see their mom
Today Show host Savannah Guthrie's sister, Annie, had just seen their 84-year-old mother for dinner hours before she was reported missing on Sunday.
Savannah Guthrie posts deeply emotional plea for prayers for her missing mother Nancy who vanished from home
Today Show host Savannah Guthrie made a heartbreaking plea for fans to keep her beloved mother in their prayers to help 'bring her home' after the elderly woman suddenly disappeared.
The frantic search for Nancy Guthrie continued on Tuesday after Pima County Sheriff Chris Nanos told the Daily Mail that he believes the 84-year-old was snatched from her bed in the middle of the night.
'We believe in prayer. We believe in voices raised in unison, in love, in hope,' Savannah wrote on Instagram. 'We believe in goodness; we believe in humanity. Above all, we believe in Him.'
Savannah Guthrie posts plea for prayers for her missing mother
Today Show host Savannah Guthrie made a heartbreaking plea for fans to keep her beloved mother in their prayers after she went missing in middle of night.
Neighbor of Savannah Guthrie's missing mother reveals eerie first sign something was terribly wrong after she vanished during 'criminal act'
A neighbor of NBC host Savannah Guthrie's missing mother, Nancy, has described the chaotic scene of authorities searching the neighborhood after she was reported missing.
The neighbor, who spoke with azcentral and requested to not be named, recalled police driving up and down the street with their lights flashing on Sunday night as a helicopter circled overhead.
Nancy lives in a $1million home in Tucson, Arizona's affluent Catalina Foothills area. The neighbor described the large police presence as 'very unusual.'
Blood found inside abducted Nancy Guthrie's home after 'forced entry'
While the extensive hunt for Savannah Guthrie's missing mother Nancy continues, police sources revealed disturbing new details about her abduction.
It comes after the Daily Mail revealed how the 84-year-old had been abducted from her bed at her $1 million home in Tucson, Arizona, late Saturday or early Sunday.
Pima County Sheriff Chris Nanos almost burst into tears Monday night when asked if he thinks Nancy is still alive.
He said he and his deputies are 'just not going to give up hope' of finding Nancy - who officials say is frail and has been without daily medication she needs to survive.