Christina Applegate's rep responds to report of hospitalization

Christina Applegate's rep responds to report of hospitalization
Source: USA Today

Christina Applegate has revealed what she would like to do "with the days I have left," and one of them is to do "shots with Cher."

Christina Applegate has been hospitalized, according to a new report.

The actress, who has been battling the effects of multiple sclerosis since 2021, is currently hospitalized in Los Angeles after being admitted in late March, TMZ reported from "sources with direct knowledge" Thursday, April 16. It's unclear whether her hospitalization is related to her diagnosis.

Applegate's rep Ame Vanlden declined to comment on whether Applegate was hospitalized or her current medical status. "She's had a long history of complicated medical conditions that she has been refreshingly open about, as evidenced in her memoir and on her podcast," her rep told USA TODAY.

Applegate's "MeSsy" podcast, which she cohosts with fellow actress Jamie Lynn Sigler who also has multiple sclerosis, went on a short hiatus at the end of March. They announced the podcast would be taking a "short break for the next few weeks" while Sigler and Applegate promoted their books.

The "Married...with Children" star told USA TODAY in late February that she was "sick as a dog" from a viral infection, speaking from bed for an interview about her memoir, "You with the Sad Eyes." She recalled not realizing how difficult it would be unearthing "all of these things that were so unbelievably horrifying in my life," which she has stuffed "into what I call my trauma ball in my stomach."

"It was like having a therapy session, and I couldn't stop," she said in the interview. "I didn't judge myself and I didn't want to judge myself, and I didn't want to edit myself either."

Christina Applegate hospitalized previously amid MS battle

The "Dead to Me" star, 54, previously said in August that she was hospitalized for a kidney infection. She shared the revelation on an episode of her "MeSsy" podcast, which she recorded while still in the hospital.

"I'm holding in [a] bag o' tears right now," she said on the Aug. 5 episode. "Just [a] bag o' tears. I sometimes fall into the nurse's arms like a freako just crying."

In a statement provided to USA TODAY at the time, Applegate said she has returned home since recording the podcast and has "been treated for the kidney infection" after seven days in the hospital.

And in March 2025, Applegate revealed on "MeSsy" that she's been in and out of urgent care constantly since being diagnosed with MS.

"For three years, since I was diagnosed, I've been in the hospital upwards of 30 times," Applegate said. "That is unimaginable, OK? They've done every test known to man on me, put so much radiation into my body from CT scans to everything else."

What is MS? Multiple sclerosis symptoms

Multiple sclerosis causes a "breakdown of the protective covering of nerves. Multiple sclerosis can cause numbness, weakness, trouble walking, vision changes and other symptoms," according to the Mayo Clinic. There is no cure.

Though symptoms may vary from person to person and depending on the location and severity of the nerve damage, some people may "lose the ability to walk on their own or move at all. Others may have long periods between attacks without any new symptoms, called remission," the Mayo Clinic says.

Common symptoms can include numbness or tingling, slurred speech, electric-shock sensations accompanying certain neck movements, trouble walking or not being able to walk at all, partial or complete loss of vision, among others, according to the clinic.

Contributing: Brendan Morrow, Anna Kaufman, Erin Jensen, USA TODAY